Absorption: ribavirin when administered orally is absorbed quickly from the gastrointestinal tract. Moreover, its bioavailability is greater than 45%.
It consists of ribavirin anavar cycle is distributed in plasma, mucous secretions and airway erythrocytes. A large number of ribavirin triphosphate accumulates in red blood cells, reaching a plateau at Day 4 and continue for several weeks after administration. Poluraspredeleniya period of 3.7 hours, the distribution volume (the V. D ) – 647 – 802 liters. In exchange reception ribavirin accumulates in plasma in large quantities. The high ribavirin concentrations (over 67%) can be detected in cerebrospinal fluid after prolonged use. Slightly bound to plasma proteins.
The time to reach maximum plasma concentration – from 1 to 1.5 hours.
Achieve therapeutic plasma concentration time it depends on the minute blood volume.
The average value of the maximum concentration in the plasma of about 5 micromoles per liter at the end of weeks 1 Hour 200 mg every 8 hours and about 11 micromoles per liter at the end of 1 week of receiving 400 mg every 8 hours.
Biotransformation: ribavirin is phosphorylated in cells of the liver to active metabolites in the form of mono-, di- and triphosphate which is then metabolized to 1,2,4 – triazolkarboksamid (amide hydrolysis and acid trikarboksilovuyu deribozilirovanie to form the triazole metabolite carboxy).
Excretion: ribavirin is excreted from the body slowly. Half-life (T 1/2 ) after receiving a single 200 mg dose of from 1 to 2 hours due to the plasma and erythrocytes of 40 days. Upon termination of a course of reception the T 1/2 is about 300 hours. Ribavirin and its metabolites are primarily excreted in the urine. Only about 10% is excreted in the feces. The unchanged for about 7% of ribavirin is displayed for 24 hours and about 10% – for 48 hours.
Pharmacokinetics in special clinical conditions: When taking the drug in patients with renal insufficiency AUC and C max of ribavirin increased, due to a decrease in the true clearance. Patients with liver failure (A, B and C degrees) pharmacokinetics ribavirin does not change. After receiving a single dose with food containing fat varies significantly ribavirin pharmacokinetics anavar cycle.
Chronic (primary patients not previously treated with interferon alpha, with aggravation after a course of monotherapy with interferon alpha, in patients refractory to monotherapy with interferon alpha), treatment is carried out in combination with interferon alpha.
Hypersensitivity, pregnancy, lactation, chronic heart failure IIb-III art, myocardial infarction, renal insufficiency (creatinine clearance – less than 50 ml / min), severe anemia, liver failure, decompensated cirrhosis, autoimmune diseases (incl . autoimmune hepatitis), not treatable thyroid disease, severe depression with suicidal intentions, children and Youth age (up to 18 years).
Women anavar cycle of childbearing age (pregnancy is not desirable), decompensated diabetes (with bouts of ketoacidosis); chronic obstructive pulmonary disease, pulmonary embolism, chronic heart failure, thyroid disease (including hyperthyroidism), bleeding disorders, thrombophlebitis, mielodeprescia, hemoglobinopathies (including thalassemia, sickle-cell anemia), depression, suicidal (including history). Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.