The drug is taken by mouth without chewing and drinking water, along with the food intake.
Patients with hepatitis C is recommended to take ribavirin at the rate of 15 mg per 1 kg of body weight, which corresponds to 800-1200 mg per day, ie, 2-3 capsules or tablets in the morning and evening 2-3 capsules or tablets. Typically, the recommended dosage for patients weighing less than 75 kg is 1000 mg per day (2 capsules or tablets in the morning and 3 capsules or tablets in the evening), patients weighing more than 75 kg are advised to take 1200 mg per day (3 capsules or tablets in the morning and . 3 capsules or tablets in the evening)
Duration of combination therapy of interferon alpha with ribavirin, anavar reviews is typically 24 – 48 weeks. In addition, for treatment-naïve patients with duration of the course is at least 24 weeks and patients with genotype 1, the course duration is 48 weeks. In patients refractory to monotherapy with alpha – interferon, and for relapsed disease course duration is at least 6 months.
On the part of the nervous system: headache, insomnia, asthenic syndrome, depression. Since the cardiovascular system: decrease in blood pressure, bradycardia, cardiac arrest. From the side of hematopoiesis: hemolytic anemia, leukopenia, neutropenia, granulocytopenia, thrombocytopenia. With digestive system: loss of appetite, nausea, hyperbilirubinemia. Allergic reactions: urticaria, angioedema, bronchoconstriction, anaphylaxis skin rash. Other: hair loss.
possible increased severity of side effects. Treatment: removal of the drug, symptomatic therapy.
Interaction with other drugs
When combined ribavirin and alpha – interferon anavar reviews indicated synergy of their action.
In the clinical application of various drugs in therapeutic doses in combination with ribavirin showed no significant interactions.
Appointment of ribavirin during treatment with zidovudine and / or stavudine when both existing HIV infection is accompanied by a decrease in phosphorylation of these drugs, resulting in HIV viremia and treatment regimen requires a change. Not detected interaction ribavirin and nucleoside reverse transcriptase inhibitors or protease inhibitors. It is therefore possible and ribavirin combined use of these drugs for the treatment of patients co-infected
Medicaments containing compounds of magnesium and aluminum, simethicone reduces the bioavailability of the drug.
should be considered teratogenic, men and women of reproductive age during treatment and for 7 months after the end of treatment should use effective contraception.
Laboratory tests (complete blood count anavar reviews with leukocyte and platelet count, determination of electrolytes, creatinine, functional liver samples) should be carried out before treatment, at 2 and 4 weeks, and more regularly.
in the treatment of ribavirin maximum reduction in hemoglobin content in most cases is observed after 4-8 weeks from start of treatment. By reducing the hemoglobin is less than 110 mg / mL should be temporarily reduce the dose of ribavirin at 400 mg per day, with a decrease in hemoglobin of less than 100 mg / ml dose should be reduced to 50% of the original. In most cases, the recommended dose modifications provide restoration of hemoglobin levels. By reducing the hemoglobin is less than 85 mg / ml taking the drug should be discontinued.
In acute manifestation giperchuvsvitelnosti (urticaria, angioedema, bronchoconstriction, anaphylaxis) use of the drug should be discontinued immediately. Transient rashes do not serve as grounds for interruption of treatment.
During treatment, those experiencing fatigue, drowsiness or disorientation, should refrain from vehicles and Occupation of driving potentially hazardous activities that require high concentration and psychomotor speed reactions.
In connection with a possible worsening of renal function elderly patients prior to use of the drug is necessary to determine kidney function, in particular anavar reviews creatinine clearance. axiolabs supplier