Overdose Symptoms of possible fatigue, headache, vomiting; very rare: changes in the blood parameters. There is one report of an unknown quantity overdose zidovudine, zidovudine when blood concentrations 16 times higher than the usual therapeutic concentrations, however, with clinical, biochemical or haematological no symptoms. Treatment of symptomatic therapy and supportive therapy.Hemodialysis anavar side effects and peritoneal dialysis are not highly effective for the removal of the body of zidovudine, but enhance the elimination of its metabolite – 5′-glucuronide of zidovudine.
The interaction with other drugs
Zidovudine mainly excreted as inactive metabolite constituting glucuronide conjugate produced by the liver. Preparations having similar path removal may potentially inhibit the metabolism .
Zidovudine used in combination antiretroviral therapy with other nucleoside reverse transcriptase inhibitors, and drugs of other groups (HIV protease inhibitors, non-nucleoside reverse transcriptase inhibitors).
The list of interactions listed below should not be considered exhaustive, but it includes a group of drugs that require careful use together with zidovudine. atovaquone: does not affect the pharmacokinetic parameters of atovaquone. Atovaquone slow transformation anavar side effects zidovudine glucuronide derivative (AUC of zidovudine at steady state increased by 33% and the maximum concentration of glucuronide are reduced by 19%). Unlikely to change in the safety profile of zidovudine dosages of 500 or 600 mg / day in the combined use with atovaquone for three weeks for the treatment of Pneumocystis carinii pneumonia. If necessary, a longer combined use of these drugs is recommended careful monitoring of the clinical condition of the patient. Clarithromycin: reduces the absorption of zidovudine. The interval between receptions of zidovudine and clarithromycin should be at least 2 hours. Lamivudine: there is a moderate increase in the maximum concentration of zidovudine, while the use of lamivudine, however overall exposure is not changed. Zidovudine has no effect on the pharmacokinetics of lamivudine. Phenytoin : while use of the drug Retrovir ® phenytoin decreases the concentration of the latter in the blood plasma, it is necessary to control the concentration of phenytoin in blood plasma when using this combination. Probenecid: reduces glucuronidation and increased mean half-life and AUC of zidovudine. Renal excretion of the glucuronide and zidovudine is reduced in the presence of probenecid. Rifampicin: a combination of the drug with rifampicin reduces the AUC of zidovudine by 48% ± 34%, but the clinical significance of this change is not known. Stavudine: Zidovudine may inhibit the intracellular phosphorylation of stavudine. Thus, it is not recommended to use stavudine simultaneously with zidovudine. Others: acetylsalicylic acid, codeine, morphine, methadone, indomethacin, ketoprofen, naproxen, oxazepam, lorazepam, cimetidine, clofibrate, dapsone, izoprinozin can disrupt the metabolism of zidovudine by competitively inhibiting glucuronidation or direct suppression of microsomal metabolism in the liver. By the possibility of using these drugs anavar side effects in combination with the drug , especially for long-term therapy should be approached with caution.
The combination of the drug , particularly in emergency treatment, with potentially nephrotoxic and myelotoxic drugs (eg, pentamidine, dapsone, pyrimethamine, co-trimoxazole , amphotericin, flucytosine, ganciclovir, interferon, vincristine, vinblastine, doxorubicin) increases the risk of adverse reactions to the drug . Should be monitored for renal function and blood formula, lower doses if necessary. Because some patients, despite therapy with , may develop opportunistic infections, you should consider the appointment of prophylactic antimicrobial therapy. This includes the prevention of co-trimoxazole, pentamidine aerosol, pyrimethamine and acyclovir. Limited data from clinical trials have not shown a significant increase in the risk of adverse reactions in the joint use of the drug anavar side effects with these drugs. anabolic steroids online pharmacy
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